L-dopa? Side effects. Have to have green tree extract. Increases dopamine, but eventually tolerance and melancholy result. So much for a long-term fix.
Serotonin reuptake inhibitors? Prescriptions, only options. Too many and serotonin syndrome kicks in, fatal.
Cigs? Serotonin-norepinephrine-dopamine. Hits all three, feels good, dies down in about 5 minutes, leaves you smelling like shit. Cancer sticks.
Cocaine? Breaks down the blood-brain barrier. Dependence. Withdrawal side effects. Cost. Danger.
Kratom? Inconsistent. Fantastic one batch, dud the next. Tastes like shit. Make your own pills, dozens of them, and swallow them. Work. Time. Dependence.
Kava? Who needs livers anyways. What's the latest? Some swear by it. Others swear it will destroy your liver.
Caffeine? Hah. We're all immune, and those who aren't get the shakes. Limited dopamine agonist. Never felt anything, myself.
So many ways to try to feel better, so many ways to kill yourself, so many prices to pay.